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Recommended dose: Oral: 10 mg once daily. Tablet should be swallowed whole; do not crush or chew.
Administer immediately following a meal; should be taken at the same time each day.
Safety and effectiveness are not established in children.
Renal impairment: Bioavailability and maximum serum concentrations are increased with mild (CrCl 60-80 mL/minute), moderate (CrCl 30-59 mL/minute), or severe (CrCl <30 mL/minute) renal impairment.
Safety data is limited in patients with severe renal impairment (CrCl <30 mL/minute). Use with caution.
Hepatic impairment: Mild hepatic impairment: Use has not been studied; use with caution.
Moderate or severe hepatic impairment (Child-Pugh class B or C): Use is contraindicated.
